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Timetable chart for mist exposure9/2/2023 ![]() Two studies compared Mm/r with Mm/r at different times and two compared MIR with MIR given at a different time. Three studies compared MIR with MIR by a different route of administration. Two studies compared oral Mm/r with rectal Mm/r. Six studies compared MIR with other opioids. Fifteen studies compared Mm/r with other opioids. Fourteen studies compared Mm/r in different strengths six of these included 24‐hour modified release products. The primary outcomes for this review were participant‐reported pain and pain relief.įifteen studies compared oral morphine modified release (Mm/r) preparations with morphine immediate release (MIR). Overall we judged the included studies to be at high risk of bias because the methods of randomisation and allocation concealment were poorly reported. Thirty‐six studies used a cross‐over design ranging from one to 15 days, with the greatest number (11) for seven days for each arm of the trial. This review contains a total of 62 included studies, with 4241 participants. We excluded six, and one study is ongoing so also not included in this update. We identified seven new studies in this update.
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